曾振灵

曾振灵

 学科:基础兽医学        
电话/传真:020-85281204/020-85284896         
电子邮件:zlzeng@scau.edu.cn         
通讯地址:广州市天河区五山路483号        
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简介


    曾振灵,男,1963年4月出生于广东省兴宁市,农学博士,二级教授 。

    广东省高等学校“千百十工程”国家级培养对象;曾任国务院兽医专业学位教育指导委员会委员、教育部高等学校动物医学专业教学指导委员会委员、中国畜牧兽医学会兽医药理毒理学分会理事长。目前担任国家兽药残留基准实验室(SCAU)主任、国家兽药安全评价(环境评估)实验室(SCAU)主任、广东省兽药研制与安全评价重点实验室主任、广东省高校兽药创新工程技术研究中心主任。兼任中国畜牧兽医学会兽医药理毒理学分会副理事长、中国畜牧兽医学会动物毒物学分会副理事长、中国毒理学会兽医毒理学分会副主任委员、农业部第一届农产品质量安全专家组成员、第一届食品安全国家标准审评委员会委员、中国兽药典第四、五届委员会和执行委员会委员、农业部第二、三届兽药残留专家委员会委员等。1996年在六福彩票大学获得兽医药理学与毒理学专业、农学博士学位。1997年破格晋升为教授。

    20多年来,长期从事兽医药理学与毒理学研究,在兽医药代动力学、新兽药研发与安全评价、动物源性食品安全与兽药残留、细菌耐药机制等方面开展了系列研究工作,相关研究成果已发表SCI收录论文80余篇,影响因子累计超过230,被引用800多次。出版专著、教材、科普书10部。获授权发明专利20多项,国家级新兽药证书3个。

    曾获“广东省优秀博士”、 “广东省高等学校千百十工程国家级人选”、“南粤优秀教师”、“广东省优秀博士论文指导教师”、“全国兽医硕士专业学位优秀论文指导教师”等荣誉。获国家科技进步二等奖1项;省部级科技进步一等奖3项、二等奖1项、三等奖3项。获国家教学成果二等奖1项,省级教学成果一等奖1项、二等奖1项;全国高等农业院校优秀教材;国家精品课程1门,国家精品资源共享课程1门,广东省精品课程1门;六福彩票大学教学名师。


杂志编委


《六福彩票大学学报》编委员会委员(2015—现在)

《中国兽医学报》编委员会委员(2006—现在)

《动物医学进展》编委员会委员(2006—现在)

《中国兽药杂志》编委员会委员(2009—现在)

《中国家禽》编委员会委员(2008—现在)

《广东畜牧兽医科技》编委员会委员(2008—现在)  


学历及培训经历


1991年9月-1996 年6月 六福彩票大学动物医学系兽医药理学与毒理学专业博士研究生,获农学博士学位。

1984年9月-1987年9月 六福彩票大学动物医学系兽医药理学与毒理学专业硕士研究生,获农学硕士学位。1979年7月-1984年7月 华南农学院畜牧兽医系兽医专业本科生,获农学学士学位。

2002年4月~2003年4月 美国University of Illinois at Champaign-Urbana兽医学院做高级访问学者。


工作经历


1987.07起在六福彩票大学兽医学院一直从事兽医药理学与毒理学的教学科研工作。晋升教员(1987.07~1990.05),讲师(1990.06~1993.09),破格晋升副教授(1993.10~1997.11),硕士生导师(1994),破格晋升教授(1997.12~),博士生导师(1998),二级教授(2011.01~

1998.05~2000.01任六福彩票大学动物医学系副主任;2001.05~2007.01任兽医学院院长;2000.01~2007.01任农业部畜禽产品质量监督检验测试中心(广州)副主任;2007.01~2015.06任农业部畜禽产品质量监督检验测试中心(广州)常务副主任。

2007.01~现在 国家兽药残留基准实验室(SCAU)主任、国家兽药安全评价(环境评估)实验室(SCAU)主任、广东省兽药研制与安全评价重点实验室主任、广东省高校兽药创新工程技术研究中心主任、兽医药理研究室主任。


研究领域


·新兽药的药代动力学、药效学

·兽药研制与安全性评价

·兽药残留与动物源性食品安全

·细菌对抗菌药的耐药机制


承担科研项目情况


·国家重点基础研究发展计划(973项目):畜禽病原菌重要耐药基因的传播机制与流行规律”(2013CB20703),2013~2017,主持

·国家自然科学基金面上项目:马波沙星与头孢喹肟半体内和体内药动药效学同步模型研究(31372480),2014~2017,主持

·农业部专项:兽药安全监管与风险评估(农财发2013、2014、2015)2014~2016

·教育部“创新团队发展计划”:兽用抗菌药安全性评价研究,2014~2016,参加

·广东省自然科学基金研究团队项目:畜禽重要病原菌耐药机制及防控技术研究,2014~2017, 参加


代表论著(*通讯作者)


[1] W. Xiong, M. Wang, J. Dai, Y. Sun, Z. Zeng*, Application of manure containing tetracyclines slowed down the dissipation of tet resistance genes and caused changes in the composition of soil bacteria, Ecotoxicology and environmental safety, 147 (2018) 455-460.

[2] D. Zeng, Z. Lin, B. Fang, M. Li, R. Gehring, J.E. Riviere, Z. Zeng*, Pharmacokinetics of Mequindox and Its Marker Residue 1,4-Bisdesoxymequindox in Swine Following Multiple Oral Gavage and Intramuscular Administration: An Experimental Study Coupled with Population Physiologically Based Pharmacokinetic Modeling, Journal of agricultural and food chemistry, 65 (2017) 5768-5777.

[3] M. Wang, Y. Sun, P. Liu, J. Sun, Q. Zhou, W. Xiong, Z. Zeng*, Fate of antimicrobial resistance genes in response to application of poultry and swine manure in simulated manure-soil microcosms and manure-pond microcosms, Environmental Science and Pollution Research, 24 (2017) 20949-20958.

[4] J. Guo, E.W. Chan, S. Chen, Z. Zeng*, Development of a Novel Quantum Dots and Graphene Oxide Based FRET Assay for Rapid Detection of invA Gene of Salmonella, Frontiers in microbiology, 8 (2017) 8.

[20] D. He, L. Liu, B. Guo, S. Wu, X. Chen, J. Wang, Z. Zeng*, J.H. Liu, Chromosomal location of the fosA3 and blaCTX-M genes in Proteus mirabilis and clonal spread of Escherichia coli ST117 carrying fosA3-positive IncHI2/ST3 or F2:A-:B- plasmids in a chicken farm, International journal of antimicrobial agents, 49 (2017) 443-448.

[5] X. Huang, L. Yu, X. Chen, C. Zhi, X. Yao, Y. Liu, S. Wu, Z. Guo, L. Yi, Z. Zeng*, J.H. Liu, High Prevalence of Colistin Resistance and mcr-1 Gene in Escherichia coli Isolated from Food Animals in China, Frontiers in microbiology, 8 (2017) 562.

[6] J. Wang, X. Yao, J. Luo, L. Lv, Z. Zeng*, J.H. Liu, Emergence of Escherichia coli co-producing NDM-1 and KPC-2 carbapenemases from a retail vegetable, China, The Journal of antimicrobial chemotherapy, (2017).

[7] L. Yi, J. Wang, Y. Gao, Y. Liu, Y. Doi, R. Wu, Z. Zeng, Z*. Liang, J.H. Liu, mcr-1-Harboring Salmonella enterica Serovar Typhimurium Sequence Type 34 in Pigs, China, Emerging infectious diseases, 23 (2017) 291-295.

[8] Y. Li, Y. Zhang, H. Ding, X. Mei, W. Liu, J. Zeng, Z. Zeng*, In vitro susceptibility of four antimicrobials against Riemerella anatipestifer isolates: a comparison of minimum inhibitory concentrations and mutant prevention concentrations for ceftiofur, cefquinome, florfenicol, and tilmicosin, BMC veterinary research, 12 (2016) 250.

[9] W. Xiong, Y. Sun, X. Ding, M. Wang, Z. Zeng*, Selective pressure of antibiotics on ARGs and bacterial communities in manure-polluted freshwater-sediment microcosms, Frontiers in microbiology, 6 (2015) 194.

[10] W. Xiong, Y. Sun, X. Ding, Y. Zhang, X. Zhong, W. Liang, Z. Zeng*, Responses of plasmid-mediated quinolone resistance genes and bacterial taxa to (fluoro)quinolones-containing manure in arable soil, Chemosphere, 119 (2015) 473-478.

[11] W. Xiong, Y. Sun, T. Zhang, X. Ding, Y. Li, M. Wang, Z. Zeng*, Antibiotics, Antibiotic Resistance Genes, and Bacterial Community Composition in Fresh Water Aquaculture Environment in China, Microbial ecology, (2015).

[12] C. Cao, Y. Qu, M. Sun, Z. Qiu, X. Huang, B. Huai, Y. Lu, Z. Zeng*, In vivo antimicrobial activity of marbofloxacin against Pasteurella multocida in a tissue cage model in calves, Frontiers in microbiology, 6 (2015) 759.

[13] D. He, J. Chiou, Z. Zeng, L. Liu, X. Chen, L. Zeng, E.W. Chan, J.H. Liu, S. Chen, Residues Distal to the Active Site Contribute to Enhanced Catalytic Activity of Variant and Hybrid beta-Lactamases Derived from CTX-M-14 and CTX-M-15, Antimicrobial agents and chemotherapy, 59 (2015) 5976-5983.

[14] F. Yang, J. Kang, F. Yang, Z. Zhao, T. Kong, Z. Zeng*, Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats, Journal of Veterinary Science, 16 (2015) 157.

[15] L. Liu, D. He, L. Lv, W. Liu, X. Chen, Z. Zeng, S.R. Partridge, J.H. Liu, blaCTX-M-1/9/1 Hybrid Genes May Have Been Generated from blaCTX-M-15 on an IncI2 Plasmid, Antimicrobial agents and chemotherapy, 59 (2015) 4464-4470.

[16] Y. Qu, Z. Qiu, C. Cao, Y. Lu, M. Sun, C. Liang, Z. Zeng*, Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model, BMC veterinary research, 11 (2015) 294.

[17] Q. Shan, C. Liang, J. Wang, J. Li, Z. Zeng*, In vivo activity of cefquinome against Escherichia coli in the thighs of neutropenic mice, Antimicrobial agents and chemotherapy, 58 (2014) 5943-5946.

[18] J. Wang, Q. Shan, H. Ding, C. Liang, Z. Zeng*, Pharmacodynamics of cefquinome in a neutropenic mouse thigh model of Staphylococcus aureus infection, Antimicrobial agents and chemotherapy, 58 (2014) 3008-3012.

[19]Yang, F., Li, Z.L., Shan, Q., Zeng., Z.L*. Pharmacokinetics of doxycycline in tilapia (Oreochromis aureus x Oreochromis niloticus) after intravenous and oral administration, Journal of Veterinary Pharmacology and Therapeutics, (2014), 37(4):388-393.

[20] G.H. LI, Q. SHAN, J. WANG, Y.F. LI, Y. GAO, Z.L. ZENG*. Metabolism of Mequindox in Isolated Rat Liver Cells, Journal of Integrative Agriculture, (2014), 13(1), 158-166.

[21] J. Shu, L. He, H. Ding, L. Wang, H. Guo, Y. Gao, E. E. Dzakah, Z. Zeng*. Synthesis of furaltadone metabolite, 3-amino-5-morpholinomethyl-2 oxazolidone (AMOZ) and novel haptens for the development of a sensitive enzyme-linked immunosorbent assay (ELISA), Analytical Methods. (2014), 6(1): 2306-2313.

[22] X.M. Liang, G.F. Guo, X.H. Huang, W.L. Duan, Z.L. Zeng*. Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B, Journal of Surgical Research, (2014), 187(2), 596-604

[23] Z.L. Zeng, H.-. Wei, J. Wang, D.C. Lin, X.Q. Liu, J.H. Liu. High prevalence of cfrproducing Staphylococcus species in retail meat in Guangzhou, China, BMC microbiology, (2014), 14: 151-156.

[24] Liqi Wang, Zhenling Zeng, Xianhui Huang,Yijuan Sua and Limin He. Matrix effects caused by phospholipids in multiresidue analysis for beta-agonists with liquid chromatography- electrospray tandem mass spectrometry, RSC Advances, (2014), 4: 25719-25728.

[25] Shan, Q., Liang, C., Wang, J., Li, J., and Zeng, Z*. In Vivo Activity of Cefquinome against Escherichia coli in the Thighs of Neutropenic Mice. Antimicrobial Agents and Chemotherapy, (2014), 58(10): 5943-5946.

[26] Wang, J., Shan, Q., Ding, H., Liang, C., and Zeng, Z*. Pharmacodynamics of Cefquinome in a Neutropenic Mouse Thigh Model of Staphylococcus aureus Infection. Antimicrobial Agents and Chemotherapy, (2014), 58(6): 3008-3012.

[27] Shan, Q., Yang, F., Wang, J., Ding, H., He, L., and Zeng, Z*.  Pharmacokinetic/pharmacodynamic relationship of cefquinome against Pasteurella multocida in a tissue-cage model in yellow cattle. Journal of Veterinary Pharmacology and Therapeutics, (2014), 37(2):178-185.

[28] Shan, Q., Wang, J., Yang, F., Ding, H., Liang, C., Lv, Z., and Zeng, Z*. Pharmacokinetic/pharmacodynamic relationship of marbofloxacin against Pasteurella multocida in a tissue-cage model in yellow cattle. Journal of Veterinary Pharmacology and Therapeutics, (2014), 37(3): 222-230.

[29] Yang F, Sun N,Sun Y X, Shan Q, Zhao H Y, Zeng  D P, Zeng ZL*. A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation. Journal of Veterinary Pharmacology and Therapeutics, (2013),36(2):192-200

[30] Yang, F., G.H. Li, X.B. Meng, L.Q. Wang, X.H. Huang, Q. Shan, D.P. Zeng, H.Z. Ding, and Z.L. Zeng*. Pharmacokinetic interactions of flunixin meglumine and doxycycline in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics, (2013), 36(1): 85-88. 

[31] Yang Fan, Huang Xian-Hui, Li Guang-Hui, Ni Heng-Jia, Zhao Yong-Da, Ding Huan-Zhong, Zeng Zhen-Ling*.


 Estimating tulathromycin withdrawal time in pigs using a physiologically based pharmacokinetics model, Food Additives & Contaminants: Part A, (2013), 30(7):1255–1263.

[32] Ma, J., J. Liu, L. Lv, Z. Zong, Y. Sun, H. Zheng, Z. Chen, and Z. Zeng*. Characterization of Extended-Spectrum beta-Lactamase Genes Found among Escherichia coli Isolates from Duck and Environmental Samples Obtained on a Duck Farm. Applied and  Environmental Microbiology, (2012), 78(10): 3668-3673.

[33] Hou, J., X. Huang, Y. Deng, L. He, T. Yang, Z. Zeng, Z. Chen, and J. Liu. Dissemination of the Fosfomycin Resistance Gene fosA3 with CTX-M beta-Lactamase Genes and rmtB Carried on IncFII Plasmids among Escherichia coli Isolates from Pets in China. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (2012), 56(4): 2135-2138. 

[34] Zeng, D., X. Shen, L. He, H. Ding, Y. Tang, Y. Sun, B. Fang, and Z. Zeng*. Liquid chromatography tandem mass spectrometry for the simultaneous determination of mequindox and its metabolites in porcine tissues. JOURNAL OF SEPARATION SCIENCE, (2012), 35(10-11): 1327-1335

[35] Shan, Q., Y. Liu, L. He, H. Ding, X. Huang, F. Yang, Y. Li, and Z. Zeng*, Metabolism of mequindox and its metabolites identification in chickens using LC-LTQ-Orbitrap mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, (2012), 881-882: 96-106. 

[36] Sun, N., J. Liu, F. Yang, D. Lin, G. Li, Z. Chen, Z. Zeng*, Molecular characterization of the antimicrobial resistance of Riemerella anatipestifer isolated from ducks. VETERINARY MICROBIOLOGY, (2012), 158(3-4): 376-383. 

[37] Li, G., F. Yang, L. He, H. Ding, N. Sun, Y. Liu, Y. Liu, Q. Shan, Y. Li, Z. Zeng*, Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration. RESEARCH IN VETERINARY SCIENCE, (2012), 93(3): 1380-1386. 

[38] Xi, W., L. He, C. Guo, Q. Cai, Z. Zeng*, Simultaneous determination of amoxicillin and clavulanic acid in dog plasma by high-performance liquid chromatography tandem mass spectrometry. ANALYTICAL LETTERS, (2012), 45(13): 1764-1776. 

[39] Wang, A., H. Ding, Y. Liu, Y. Gao, Z. Zeng*, Single dose pharmacokinetics of terbinafine in cats. JOURNAL OF FELINE MEDICINE AND SURGERY, (2012), 14(8): 540-544. 

[40] Yang, F., H.W. Liu, M. Li, H.Z. Ding, X.H. Huang, Z.L. Zeng*, Use of a Monte Carlo analysis within a physiologically based pharmacokinetic model to predict doxycycline residue withdrawal time in edible tissues in swine. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, (2012), 29(1): 73-84. 

[41] Jiang, H., D. Lue, Z. Chen, X. Wang, J. Chen, Y. Liu, X. Liao, J. Liu, Z. Zeng*, High prevalence and widespread distribution of multi-resistant Escherichia coli isolates in pigs and poultry in China. VETERINARY JOURNAL, (2011), 187(1): 99-103.

[42] Zheng, Y., Y. Liu, H. Guo, L. He, B. Fang, Z. Zeng*, Molecularly imprinted solid-phase extraction for determination of tilmicosin in feed using high performance liquid chromatography. ANALYTICA CHIMICA ACTA, (2011), 690(2): 269-274.

[43] Guo, H., K. Liu, Y. Liu, B. Fang, M. Liu, L. He, Z. Zeng*, Molecularly imprinted solid-phase extraction for the selective determination of valnemulin in feeds with high performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, (2011),  879(2): 181-185. 

[44 ] Zeng, Z., G. Deng, X. Shen, M. Rizwan-Ul-Haq, D. Zeng, H. Ding, Plasma and tissue pharmacokinetics of danofloxacin in healthy and in experimentally infected chickens with Pasteurella multocida. J Vet Pharmacol Ther, (2011), 34(1): 101-104.

[45] Zeng, D., C. Lin, Z. Zeng*, X. Huang, L. He, Multi-Residue Determination of Eight Anabolic Steroids by GC-MS in Muscle Tissues from Pigs. AGRICULTURAL SCIENCES IN CHINA, (2010), 9(2): 306-312. 

[46] DING, H., Y. LI, Z. CHEN, M. RIZWAN-ul-HAQ, Z. ZENG*, Plasma and tissue cage fluid pharmacokinetics of marbofloxacin after intravenous, intramuscular, and oral single dose application in pigs. Journal of Veterinary Pharmacology and Therapeutics, (2010), 33(5): 507-510.

[47] Zeng, Z*., J. Wu, G. Yang, Z. Chen, X. Huang, and H. Ding, Study of colistin depletion in duck tissues after intramuscular and oral administration. J Vet Pharmacol Ther, (2010), 33(4): 408-410


写给学生的话
 


  选择兽医药理学与毒理学研究方向,它是应用基础学科,与国家的重大需求密切相关。只要脚踏实地,多动脑、多动手实践,努力工作,美好的远景就在你的眼前。